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32,33 Thus, due to the complexity of the HIF signaling cascade and intricacies of nephron anatomy, substantial uncertainty remains regarding the impact of available treatments on HIF signaling and whether such alterations are beneficial to patients with DKD
The labile iron pool: characterization, measurement, and participation in cellular processes(1) Free Radic Biol Med
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Efficacy data remain limited
(2) Hcy may negatively affect glutathione peroxidase activity and thus transcription of glutathione
