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While the injectable route of administration in Semaglutide / Cyanocobalamin Injection bypasses the need for gastrointestinal absorption, patients receiving high-dose or long-term metformin therapy may have increased B12 requirements that should be considered when determining appropriate dosing

A common investigational regimen employs 0.5 g kg1 of combined amino acids (maximum 40 g total), infused over 30 - 45 minutes with equal parts arginine and citrulline

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