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Description
This interplay between inflammation, OS, insulin resistance, and hyperglycemia perpetuates a detrimental cycle, elevating the risk of diabetesrelated complications 4 (Figure 1)

Njoo et al., 2015)

In humans, AMPK-mediated HMGCR Ser872 phosphorylation inhibits the activity of HMGCR and decreases cholesterol production 67

Inflammation Reduction Glutathione calms chronic inflammation, which is a root cause of many diseases such as heart disease, diabetes, and arthritis

297 : G907G917

Ongoing trials and regulatory developments in MASLD Significant advances have been made in the clinical development pipeline for MASLD, with several therapeutic agents progressing to late-stage trials and achieving key regulatory milestones
