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Satake W., Nakabayashi Y., Mizuta I., et al., Genomewide Association Study Identifies Common Variants at Four Loci as Genetic Risk Factors for Parkinson's Disease, Nature Genetics 41, no

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In humans, L2HG is produced by malate and lactate dehydrogenases especially at acidic conditions caused e.g., by hypoxia 37

The Na+/Ca2+ antiport enables sodium exportation from cells based on the intracellular calcium concentration ( Reperfusion triggers a localized microvascular and systemic reaction, resulting in further tissue damage ( How the IRI influences the transplant outcome Experimental implications IRI in the skin and subcutaneous tissue IRI in the skin has been reported in several publications, not only in VCA but also in flap surgery (31)

In addition, GSH depletion also suppresses lipogenesis by downregulating key lipogenic genes at the transcriptional level, further protecting against MASLD

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