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Both SARS-CoV and high levels of intracellular calcium ions would induce ER stress [120, 132]

2015;7(Suppl 2):S554-558

This seems to exonerate the spice which for millennia has been considered a panacea for all illnesses, indicating that the supposed Curcuma longa -related hepatotoxicity would be a baseless accusation

Competing interests All authors declare that they have no commercial or other associations that may pose a conflict of interest

Upon engagement of PD-1 by its ligand PD-L1, the immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM) within the PD-1 cytoplasmic domain become phosphorylated

6-thioguanine triphosphate (6-Thio-GTP) derived from 6-mercaptopurine leads to the mitochondrial-dependent apoptotic death of T-cells via the specific binding and inhibition of the small GTPease, Ras-related C3 botulinum toxin substrate 1 (Rac1) [127]
