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In the HOPE study, supplementation of 400 IU (=268 mg) of vitamin E/day in mild to moderate CKD patients has no effect on cardiovascular outcomes and overall mortality and therefore supplementation of vitamin E is not recommended (HOPE Study Investigators, 2000)

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Notably, intranasal melatonin has demonstrated effectiveness in improving sleep in proof-of-concept studies [242]

[DOI] [PubMed] [Google Scholar] 23.Giustarini D, Dalle-Donne I, Colombo R

L-theanine and cystine, as supplements, performed well in the prevention of oxaliplatin-induced peripheral neuropathy in mouse models (44)

10.1142/s0192415x08006302 15 ChenX.ShiC.HeM.XiongS.XiaX