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Microbial adhesion to the epithelium could initiate a sequence of inflammatory responses by activating signal transduction via TLRs and zonulin signaling, leading to the loss of TJ integrity

This mechanism regulates epithelial cell polarization, which plays an important role to maintain physiological functions, such as tissue barrier and gas exchange in healthy epithelial cells

Martin LP, Sill M, Shahin MS, Powell M, DiSilvestro P, Landrum LM, et al

SHR mice

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Miller B, Kim SJ, Kumagai H, Mehta HH, Xiang W, Liu J, et al

Reducing dose or discontinuing use typically resolves these issues