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Figure 4 In general, all immune cells are affected by aging ( In addition, one of the hallmarks of immune senescence is inflammation, which refers to an age-related systemic state of sterile, chronic and low-grade inflammation characterized by the upregulation of blood markers of inflammation and is considered to be a consequence of increasing chronological age, as well as a hallmark of biological senescence, multimorbidity and mortality risk ( In conclusion, the relationships among immune senescence, chronic inflammation and oxidative stress are intertwined and complex

Illustratively, BPC 157 therapy also counteracts the effect of L-NAME, which increases the thiopental loss of the righting reflex seven times

doi: 10.1210/jcem.87.4.8421 197

doi: 10.1016/j.ejmech.2015.04.040 132 PolizziA.SantonocitoS.Lo GiudiceA.AlibrandiA.De PasqualeR.IsolaG

[(1) One patent Issued (3/20/12) Lipidomic approaches to determine drug response phenotypes in cardiovascular disease Patent # 8137977, expires 12/10/27