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Generally safe

Cataplerosis Given that metabolic intermediates from various pathways can be added to the TCA cycle via the process of anaplerosis, it is important that these intermediates be effectively oxidized and/or disposed of so as to prevent their accumulation in the mitochondrial matrix

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That's why the research had to be suppressed

[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Sun S, Liu S, Duan SZ, Zhang L, Zhou H, Hu Y, et al

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