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Participants are being monitored for unsolicited adverse events, including serious adverse events, throughout the study [from Dose 1 through 1 month (all unsolicited adverse events) or 6 months (serious adverse events) after the last vaccination]

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These disorders, which are common in many brain diseases, for example, a progression of mild cognitive impairment to AD, lead to a severe reduction in cerebral blood flow (up to 40%), can significantly limit drug accumulation within brain lesions even after BBB penetration

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No serious adverse events have been reported in published studies

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