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Mitragynine was used as a surrogate for kratom due to being the most abundant alkaloid in the K51 product, 5 as well as a potent reversible inhibitor of CYP2D6 activity and time-dependent inhibitor of CYP3A activity in intestinal and/or liver microsomes

[00:07:00] Possible drugs are not worth the investment to take it through FDA approval because of that

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