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Mayo Clinic notes that there is no solid proof B12 injections help with weight loss in people who are not deficient

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Sensitivity or Allergies to B12 or Its Components: Some individuals may have an allergic reaction to the preservatives or additives in B12 injections, especially those with known sensitivities to certain medications or substances

I am a somewhat regular user and usually will use for 2 months and then cycle off for a month or the results I see seem to diminish