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In the meanwhile, they achieve the uptake of essential nutrients and clearance of exogenous substances via carrier proteins (e.g., glucose transporter, GLUT) and efflux pumps (e.g., P-glycoprotein, P-gP) on the cell membrane, realizing regulation of transmembrane transport processes

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When the blood glucose level is high (a condition known as hyperglycemia), it can induce harmful changes in the brain, such as inflammation, oxidative stress, and damage to brain cells

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