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Mariano Malaguarnera, Lisa Cammalleri, Maria Pia Gargante, Marco Vacante, Valentina Colonna, Massimo Motta, l-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial2, The American Journal of Clinical Nutrition, Volume 86, Issue 6, 2007, Pages 1738-1744, ISSN 0002-9165, Colombani, Paolo & Wenk, Caspar & Kunz, Iris & Krahenbuhl, Stephan & Kuhnt, Martina & Arnold, Myrtha & Frey-Rindova, Petra & Frey, Walter & Langhans, Wolfgang

& Campbell, R

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Furthermore, genetic deletion/knockdown of FMO3 stimulated beiging of white adipose tissue and conferred protection against obesity in mice (Schugar et al., 2017)

Vitamin D deficiency has been linked with a higher incidence of headaches, per the 2024 review, and supplementing has been shown to significantly reduce the number of headache days per month