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These impairments in oxidative metabolism are associated with reduced expression of a metabolic and mitochondrial transcriptional programme controlled by the peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1) transcriptional coactivator [10], encoded by the PPARGC1A gene

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Clinical data shows 24.2% average reduction

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[DOI] [PubMed] [Google Scholar] 42.Hornung T.C., Biesalski H.-K

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2011;15(Suppl 2):S99-S106

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