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Cytokines released in peripheral tissues activate vagal afferents, resulting in an inflammatory reflex in which efferent vagus nerves inhibit inflammation by suppressing cytokine production via the cholinergic anti-inflammatory pathway

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It was subsequently shown that free glutamine is abundant in certain plants, but relatively little was known about the metabolism of glutamine until the1930s, when it was directly demonstrated that glutamine is a component of proteinS3 and when Hans Krebs first described the capacity for glutamine hydrolysis and glutamine synthesis in mammalian tissues

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