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Dysregulated copper transport in multiple sclerosis may cause demyelination via astrocytes

This selection process aimed to filter for high-quality evidence regarding the synergistic efficacy of combined lifestyle interventions

In a given multicenter trial, 11 percent of sites fail to enroll a single patient, 37 percent of sites do not meet enrollment targets, and studies are typically lengthened (often to double the original timeline) to satisfy enrollment targets [3]thereby constituting a significant use of resources to launch clinical trials that fail or struggle to reach the desired return on that investment

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A symptom intensity rating (SIR, rated 17) was derived for each symptom and taken as an additional measure of clinical severity

(2003) 285:G2030
