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These features are essential for oxygen transport, since RBCs have to undergo repeated shape changes without fragmentation, to assure their passage and oxygen perfusion through all vascular networks, namely, through capillary blood vessels with smaller lumen diameter than that of RBCs [6, 7]

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76 The altered membrane potential of hepatocytes after adipose deposition causes -aminobutyric acid (GABA) release and inhibits the vagus nerve, which is also involved in hyperinsulinemia

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