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Brain, J

In the present study, elevated PGA levels were observed among 89% of symptomatic TTR-V30M patients and in 63% of asymptomatic carriers relative to the median of healthy controls (Table 1)

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Different mechanisms, different side-effect profiles

Aos, upon binding to cell-surface receptors on neurons, disrupt signal transduction, leading to a sustained interruption of intracellular Ca 2+ signaling through increased N-methyl-D-aspartate (NMDA) receptor-dependent Ca 2+ influx [77]
