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Similar content being viewed by others Introduction Keloids form a dysregulated wound-healing process characterized by aggressive tumor-like growth beyond the boundaries of the initial insult and a high rate of recurrence

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doi: 10.3389/fcell.2025.1671152 Received 22 July 2025 Revised 08 October 2025 Accepted 20 October 2025 Published 01 December 2025 Volume 13 - 2025 Edited by Nimanthi Jayathilaka, University of Kelaniya, Sri Lanka Reviewed by Theodoros Androutsakos, National and Kapodistrian University of Athens, Greece Arturo Raya-Sandino, University of Michigan, United States Updates Copyright 2025 Ferris, Subitoni Antonio and Al-Sadi

Fibrosis is a highly dynamic process associated with overactivated fibroblasts in organs, such as the heart, lung and kidney 8,38,39