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Our approach is comprehensive, addressing the root causes and regeneration simultaneously

PPAR promotes further M1 macrophage polarization and the production of pro-inflammatory cytokines, which is catastrophic for islet cells (45)

Samson DJ, Gachabayov M, Latifi R (2021) Biologic mesh in surgery: a comprehensive review and meta-analysis of selected outcomes in 51 studies and 6079 patients

This specific property has become the focus of numerous research strategies, such as the development of senolytic agents like FOXO4-DRI, which selectively disrupt the FOXO4p53 interaction, thereby enabling the targeted elimination of dysfunctional cells

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To balance risks and benefits, expert opinions emphasize the importance of individualized dosing, shared decision-making, and careful patient selection