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A (served as the control), B (received 3 mg/kg CdCL2), C (received 100 mg/kg PREOG), D (received 200 mg/kg PREOG), E (received 100 mg/kg PREOG+3 mg/kg CdCL2) and F (received 200 mg/kg PREOG+3 mg/kg CdCL2) treatment continued to postnatal day 29 before weaning

In this study, we measured tail flick latency (TFL), arterial blood gas (ABG) chemistry, Alveolar-arterial gradient, and ventilatory parameters by whole body plethysmography to determine the responses elicited by bolus injections of fentanyl (75 g/kg, IV) in male adult SpragueDawley rats that had received a bolus injection of GSHee (100 mol/kg, IV) 15 min previously