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The better effect of LCLN than LC was evidenced by the findings of earlier studies 92,100 , likely due to physical attributes (including shape, size, and zeta potential), alongside enhancements in encapsulation efficiency, drug content, drug loading capacity, drug release, and in vitro release of the formulated LC-SLNs, all of which were optimized in the niosomal form 19

The relevant promoter mutations were located in the tip of the 3terminal stem-loop SL1 46 and have been shown to affect negative strand synthesis by disturbing recognition of a genotype-specific sequence in the tip of SL1 by NS5B 46

The median cumulative radiation doses needed for therapeutic efficacy are also quite highoften well in excess of 50 Gray (Gy) [63,76]

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This can make them difficult to diagnose as they may be mistaken for other skin conditions