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All study procedures and protocols were approved in advance by an independent review board (The Institute of Regenerative and Cellular Medicine)

AKR inhibition suppressed ROS generation in cancer cells emphasizing the role of AKR in stimulating ROS-induced oncogenic signaling [25] (Fig

Smoking also reduces saliva production that normally helps neutralize refluxed acid and clear it back to the stomach

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Figures were created with UCSF Chimera and ChimeraX, developed by the Resource for Biocomputing, Visualization, and Informatics at the University of California, San Francisco, with support from National Institutes of Health R01-GM129325 and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases