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Although multiple mechanisms have been proposed to explain the unique tumor suppression effects of p53, the specific function necessary for these effects remains unknown

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Drugs such as DFOM and deferiprone can chelate iron and thereby inhibit ferroptosis

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Among the three DHARs, DHAR2 was the most obviously responsive, being clearly induced in cat2 , flu , and by external H 2 O 2 or paraquat

10.3390/cancers11111755 Summary Keywords NRF2KEAP1 pathway, breast cancer, BMAL-1, circadian rhythm, chemoresistance Citation Bevinakoppamath S, Ramachandra SC, Yadav AK, Basavaraj V, Vishwanath P and Prashant A (2022) Understanding the Emerging Link Between Circadian Rhythm, Nrf2 Pathway, and Breast Cancer to Overcome Drug Resistance