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Too much spray at once can cause the peptide to drain away Tilt Your Head Back : A slight head tilt helps the spray reach the upper nasal cavity

10.1016/j.ejphar.2019.01.030 [DOI] [PubMed] [Google Scholar] Sikiric P., Hahm K

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This affects numerous systems in the body including digestion, absorption of nutrients, respiration, blood circulation, elimination of waste from the body and regulation of body temperature

About DSNY Archived May 23, 2007, at the Wayback Machine "DSNY The City of New York Department of Sanitation"

At the general level, this dual (modulatory) action (i.e., either hypertension or hypotension reversed toward normal blood pressure) applies to the NO-systems effects as a whole, as well [11,29]