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Microglia serve as a neuroimmune substrate for stress-induced potentiation of cns pro-inflammatory cytokine responses

This also contributes to reduced food intake at subsequent meals

PMID 10386505

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Although both residues are located in the vicinity of an arginine residue, the charge-charge interaction between Asp101 and Arg14 in S-crystallin is likely to diminish the important function of arginine residue, which is to stabilize the negatively charged intermediate state (the Meisenheimer complex) during catalysis 19

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