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4 Novo Nordisk / NEJM CagriSema (cagrilintide + semaglutide)Trial data on the investigational dual GLP-1 + amylin combination CagriSema

However, side effects of these drugs are common, and especially myelotoxicity or emerging viral resistance are major limitations of prolonged usage (7)

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The expression of PGC1 and OXPHOS activities are increased in the long-living Ames dwarf mice (lack of GH, prolactin, and thyroid-stimulating hormone), demonstrating a negative effect of GH on mitochondrial biogenesis (Westbrook et al., 2009