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[DOI] [Google Scholar] Bagheri R, Chakraborty KB, Scott G

Intraplaque hemorrhage and erythrocyte derived iron: a catalytic accelerator niche The presence of intraplaque hemorrhage brings erythrocytes and hemoglobin to the site of the plaque, and consequently, delivers heme iron, thus creating an environment conducive to oxidative stress ( Metabolic comorbidities as systemic modifiers of plaque ferroptosis thresholds Atherosclerotic plaques are influenced by various systemic metabolic states which can create an environment in the plaque microenvironment that is conducive to ferroptosis ( Gut microbiota as a remote regulator of plaque ferroptosis thresholds The gut microbiota has emerged as a non-traditional driver of atherogenesis, with dysbiosis linked to increased intestinal permeability and systemic inflammation ( TMAO, generated from dietary choline and carnitine by gut bacteria with subsequent hepatic oxidation, is an established pro-atherogenic metabolite

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PLOS ONE 10 , e0142680 (2015)