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In addition, daratumumab has been conjugated to DOTA for radiolabeling with the alpha-emitter actinium-225 ( 225 Ac), showing potent CD38-positive tumor cell-killing in vitro and enhanced anti-tumor activity (~ 30-fold) in vivo without significant side effects [131]

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Cui Y, Zhang L, Wang W, Ma S, Liu H, Zang X, Zhang Y, Guan F (2019) Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/-catenin pathway

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