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In an inflammatory condition, LDHA can enhance the production of ROS in chondrocytes (40)

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Smith et al., 2019

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A., Kramr E

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In addition, the survival rate of OC cells decreased significantly after POL treatment, while the ferroptosis inhibitors Ferrostatin-1 and Deferoxamine were able to reverse this phenomenon, further proving that POL induces cell death through iron-dependent lipid peroxidation

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