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Safety also depends on the type of supplement and individual health conditions

Simply, GH and IGF1 regulate the process by promoting cell proliferation through janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5) signaling pathway or phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and mitogen-activated protein kinase/extracellular regulated MAP kinase 1/2 (MAPK/ERK1/2) pathways, inducing homologous recombination (HR) or non-homologous end joining (NHEJ) to repair DNA damage and decreasing pro-apoptotic molecules (Bax, caspase3) (Valenciano et al., 2012

[DOI] [PubMed] [Google Scholar] 133.Riederer P, Youdim MBH, Birkmayer W, Jellinger K

Environ Technol Innov 32:103361 Yadav R, Arora P, Kumar S, Chaudhury A (2010) Perspectives for genetic engineering of poplars for enhanced phytoremediation abilities

Kinnunen S, Oksala N, Hyypp S, Sen CK, Radak Z, Laaksonen DE, Szab B, Jakus J, Atalay M

In neurodegenerative disorders, such as Parkinsons disease [94], ferroptosis is a catalyst for neuronal degeneration and cell death