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In general, most supplements appear to be safe to combine with rosuvastatin, but there are some exceptions

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This can be through (a) the direct alkylation of DNA through the activation of drugs like mitomycin C and RH1 into alkylating groups, (b) the inactivation of heat shock proteins by geldanamycin hydroquinones generated by the enzyme, and (c) in contrast to the known metabolic process of NQO1, certain naturally occurring or synthetic quinone compounds produce labile forms of hydroquinone [39,40,41,42]