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Moreover, oxidative stress activates glial cells in the spinal cord, particularly microglia and astrocytes, which release proinflammatory cytokines and amplify nociceptive signaling (Zhu et al., 2022

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For patients requiring surgical procedures, recent 2024 multi-society guidance (including the American Society of Anesthesiologists) indicates that most patients can continue GLP-1 receptor agonists perioperatively

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