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Within dopaminergic neurons of the SNpc, these pathways promote oxidative stress, impair mitochondrial dysfunction, and promote apoptotic signaling [13]

Given that T2D patients have up to 6070% likelihood of experiencing diabetic neuropathy, what might sometimes be considered to be diabetic neuropathy may, at least in part, be a neuropathy induced by vitamin B 12 deficiency as a consequence of concomitant use of metformin alongside PPI/HRAs
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