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Research on the Anti-Ageing Mechanism of Prunella vulgaris L

Quercetin exerts neuroprotective effects through the upregulation of p-Akt expression, downregulation of p-ASK1, p-JNK3, and cleaved caspase-3 expression, and inhibition of neuronal apoptosis (Pei et al., 2016)

Others have considered the role of glycogen synthase kinase-3 (GSK3) instead of the more well-known roles for GRKs and PKC in receptor desensitization (Alcntara-Hernndez et al., 2020)

In addition, nicotinamide adenine dinucleotide phosphate (NADPH) is the standard complex enzymatic system for the generation of ROS, and it seems like a basic source for glucose-induced ROS production in the tissues/cells of DM prototypes (Jersin et al., 2021