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Murphy MG, Bach MA, Plotkin D, Bolognese J, Ng J, Krupa D, Cerchio K, Gertz BJ

This is because there is a mutation or abnormality in the relevant gene: COL1A2 for cvEDS, and COL1A1 and COL3A1 for vEDS (no gene has been identified yet for hEDS)

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Blackened 96-well-plates were used in a PerkinElmer Victor3 multilabel counter containing a final well volume of 200 L in 0.1 M potassium phosphate buffer (pH 7.5), 1 mM EDTA

Several mechanisms have been reported as responsible for cisplatin resistance, such as reduced drug uptake by a decrease in CTR1 expression, increased efflux by ABC transporters, augmented induction of stress response chaperones, induction of autophagy, inactivation of apoptosis pathway signaling, inactivation by thiol-containing proteins, and functional changes in DNA repair pathways 6,7,8,9,10,11