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TB-500's structure includes actin-binding domains, and research investigates its effects on actin polymerization and cellular motility

Cellular Microbiol 17(12):18111832 Bernard MD, Moschioni M, Habermann A, Griffiths G, Montecucco C (2002) Cell vacuolization induced by Helicobacter pylori VacA cytotoxin does not depend on late endosomal SNAREs

Qualitative methods in early-phase drug trials: Broadening the scope of data and methods from an RCT of N-acetylcysteine in schizophrenia

Rrf2 Rrf2 repressors are dimers consisting of an N-terminal DNA-binding winged helical domain composed of five helices and two -strands, and a C-terminal helical dimerization domain dominated by a long helix, and thus superficially resemble MerR-family activators (Section 3.2.3)

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However, though TNF- inhibitor, methotrexate, has been prescribed to treat children and adolescents, it has not been approved by the European Medicine Agency, thus making it a good candidate for clinical research assessment