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Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction

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While many cellular components of cNF are not well studied, a role has been demonstrated for mast cells in neurofibroma growth/maintenance

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Garg N, Kapono C, Lim YW, et al

Hall of fame among pro-inflammatory cytokines: interleukin-6 gene and its transcriptional regulation mechanisms