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It undergoes significant first-pass metabolism in the liver and intestines, where the enzyme arginase breaks it down, reducing bioavailability

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Weaver and His Intriguing Dissection of Harriet Cole. Translational Research in Anatomy 10 (2018): 79

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doi:10.1007/s40292-019-00324-6 Wong RH, Berry NM, Coates AM, et al