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Enhanced Tim-3 expression in subpopulation of hepatic macrophages of mice with methionine and choline deficient diet indicated evidences, supporting the important role of Tim-3 in alleviating liver injury by regulating ROS production and proinflammatory cytokine secretion from macrophages [87]

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Additionally, because the survival mechanism of fat grafts has not yet been fully elucidated, there is a lack of effective targeted interventions