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RSL3 binds to the nucleophilic active site of GPX4, and then reduces the expression level of GPX4 most effectively through chloroacetamide moiety (Jelinek et al., 2018), thus inactivating GPX4, producing lethal ROS accumulation and inducing ferroptosis

In chronic plantar fasciitis, this organization becomes disrupted, with collagen fibers losing their alignment and the tissue becoming thickened yet weaker

These agents normally bind the glutamate receptor and the complex is transported across the cell resulting in reduced concentrations, hence attenuating effects of these drugs

[DOI] [PMC free article] [PubMed] [Google Scholar] 231.Barbalho S.M., Direito R., Laurindo L.F., Marton L.T., Guiguer E.L., Goulart R.A., Tofano R.J., Carvalho A.C.A., Flato U.A.P., Capelluppi Tofano V.A., et al