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In the development and screening of natural products, two new antifungal agents, fellutamides C and D, were isolated and clarified from fungal fermentations, which exhibit proteasome inhibitory activity

Each well was precoated with 40 L of growth factor-reduced Matrigel (#356234, Corning), which was solidified at 37 C for 10 min prior to cell seeding

Swirl or roll gently

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Bueno-Carrasco, M \) shows a model of the TH active site changes on phosphorylation of serine 40 using structural and molecular dynamics approaches that led to the cartoon model above

The paper does not report systemic toxicity panels, liver enzymes, or serum copper metrics