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Proviral insertion in murine lymphomas 2 (PIM2) is reported to act as an oncogene in gastric cancer, controlling apoptosis via ROS-triggered ER stress, and promoting the development of gastric cancer (72)
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Free Radic Res 1997
Finally, cobamides can also directly influence levels of transcription and translation through interacting with riboswitches, where binding of specific cobamide forms to regulatory regions within the mRNA controls the production of encoded proteins (Section 5.3.1) [21,22]
Despite its limited penetration through the BBB, everolimus exhibited notable attributes that favored its efficacy within the CNS
