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However, that study demonstrated that in early disease these cells are located in zone 3 of the hepatic acinus, distal to the zone 1 iron-laden hepatocytes, implying hepatic stellate cells are activated into collagen-producing myofibroblasts by soluble mediators released from iron-damaged hepatocytes rather than by iron per s [75, 85]

The transcobalamin-bound fraction, known as holotranscobalamin or active B12, accounts for 6%-20% of bound vitamin B12

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