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The original genetic-validation study used antisense oligonucleotide-mediated knockdown of NNMT in adipose tissue of mice on a high-fat diet, with whole-body and adipose-tissue metabolic endpoints measured against scrambled-oligonucleotide controls [2]

[DOI] [PubMed] [Google Scholar] 6.Sikiric P., Seiwerth S., Rucman R., Drmic D., Stupnisek M., Kokot A., Sever M., Zoricic I., Zoricic Z., Batelja L., et al

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