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Key considerations if a patient discloses combined use include: Gastrointestinal effects : Both agents may independently cause nausea, vomiting, or appetite suppression

However, a larger follow-up pivotal trial, known as METAOD006 (or OPTIONS), enrolled a bigger cohort and failed to replicate statistically significant weight loss, leading the sponsoring company, Metabolic Pharmaceuticals, to halt the formal drug-development program in 2007

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It should be clear and free of particles
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