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18 Elevated intracellular levels of cAMP, in turn, lead to broad-spectrum anti-inflammatory effects, such as decreased liberation of inflammatory mediators derived from neutrophils, reduced cytokine secretion, 16 downregulation of cell surface markers in various types of cells, and decreased incidence of programmed cell death

Study has shown that silicosis patients exhibit reduced serum levels of vitamin C compared to individuals not exposed to silica (81)

Inhibition of mitochondrial p53 accumulation by PFT- prevents cisplatin-induced peripheral neuropathy

doi: 10.1080/13510002.2016.1140406 38 HsuC

Figure 13 4 Discussion 4.1 Effect of glutathione on growth performance and hepatic lipid metabolism in bullfrogs Relatively many studies have been conducted to show that glutathione has a promoting effect on the growth and antioxidant capacity of aquatic animals ( 4.2 Serum antioxidant capacity and effect on hepatic lipid metabolizing capacity in bullfrogs with glutathione The animal body due to the normal metabolic process is prone to produce many less stable unpaired electron molecules, atomic groups or chemical groups ( Total cholesterol, including free cholesterol and cholesteryl esters, is synthesized and stored in the liver, and its serum concentration can be used as an indicator of lipid metabolism ( 4.3 Regulation of serum metabolites and hepatic metabolites in bullfrogs by glutathione In the serum metabolomics and liver metabolite assay of bullfrogs, it was found that the significant differential metabolites in the three comparisons were mainly lipids and lipid-like molecules, as well as some organic acids and their derivatives