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ChenDIrelandSJDavisLSKongXStoweAMWangYet alAutoreactive CD19+CD20- plasma cells contribute to disease severity of experimental autoimmune encephalomyelitis

The majority of the events were due to a single isolate (85%)

Conclusions Some defects in CoQ biosynthesis induce an increase in life span in animal models, most likely due to either a mild reduction in the flow of electrons in the mitochondrial respiratory chain and the subsequent decrease in ROS production or early mitochondrial dysfunction and physiological adaptation to this conditionthe latter phenomenon being compatible with the concept of mitohormesis

However, the absence of a documented interaction does not necessarily establish the safety or efficacy of this combination

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The combination may produce greater vascular effects than either component alone, though this synergistic hypothesis requires further clinical validation