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Metabolic health and insulin sensitivity NNMT activity climbs in the fat tissue of people with obesity and type 2 diabetes, which is exactly why the enzyme drew interest as a target for metabolic syndrome in the first place

These studies compared daily oral doses of 1,0002,000 mcg of cyanocobalamin to traditional intramuscular (IM) injections
Pawlak, Remy

So far, Asprey says hes spent at least a million dollars hacking his own biology, and making it to 2153 will certainly take several million more
Lancet 385 , 857866 (2015)

All effects are dose-dependent and typically resolve after dosage adjustment